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Research Use Only

Residual Solvents

Quantifies volatile organic solvents left in the material from synthesis, purification, and drying.

Method
GC-MS
Turnaround
5 business days from sample receipt

What it determines

The sample is sealed in a vial and warmed so that volatile components partition into the headspace above it. A portion of that headspace is drawn into the gas chromatograph, where the solvents separate by boiling point and by affinity for the column, each arriving at the detector at a characteristic time.

The mass spectrometer identifies each solvent from its fragmentation pattern and measures its abundance. Concentrations are calculated against calibration standards prepared for every solvent on the method's list, so each reported value traces back to a standard run in the same sequence.

Practical notes

  • Solvent content changes with storage. A vial left open, or one held warm, loses volatiles, and the result reflects the sample as it arrives.
  • Headspace analysis consumes the aliquot taken for it.

Tell us which assays you want and we will send sample intake instructions, including the quantity required.